IBS symptoms intensify when anxiety and stress disrupt the GBA balance ^2-4

Physical symptoms of IBS are linked to neuro-transmitters, causing abnormal gut motility and sensory dysfunctions.²

Emotional states like anxiety and depression caused by stress increase the risk of hypersensitivity.⁵

The only IBS treatment that combines the antispasmodic effects of Clidinium Bromide and the anti-anxiety action of Chlordiazepoxide ⁶

Relief for the Stomach ¹

LIBRAX^® contains clidinium bromide which has a pronounced anti-spasmodic and anti-cholinergic effect on the gastrointestinal tract. ⁷

LIBRAX^® containing clidinium bromide has antimuscarinic effects on the somatic components of IBS namely: ^8,9

• Decreased smooth muscle motility ⁹
• Decreased GI activity ⁹

Relieving the symptoms of constipation, flatulence, diarrhoea and abdominal discomfort.⁹

Peace for the Mind ¹

Benzodiazepine use should be expanded in GI disorders associated with anxiety.¹⁰

Benzodiazepines:

• Have muscle relaxant properties
• Contribute to patient well–being
• May facilitate the transition for pharmacotherapy to psychotherapy*

Treatment should be started with the lowest recommended dose.

• Reassess patient regularly. Re-evaluate continued treatment, especially if patient is symptom-free
• The maximum dose should not be exceeded
• The overall duration of treatment generally should not be more than 8 – 12 weeks, including a tapering off process^†

*The tri-cyclic antidepressants, the SNRI’s and the SSRI’S are less suited for this role.
^† Re- evaluate the patient carefully if this duration is to be exceeded.
IBS: irritable bowel syndrome; GBA: gut-brain axis; GI: gastro intestinal

Find balance with Librax^®

Relief for the Stomach, Peace for the Mind ¹

The 2-in-1 treatment for stress- related IBS